Knowledge Check Solutions
1) Stratum corneum - This is the correct answer.
The epidermis (and particularly the stratum corneum) is the only layer that is important in regulating penetration of a skin contaminant.
2) Increasing hydration and disruption of the stratum corneum - This is the correct answer.
Water plays an important role in dermal absorption. Normally, the stratum corneum is partially hydrated (~7% by weight). Penetration of polar substances is about 10 times as effective as when the skin is completely dry. Additional hydration can increase penetration by 3-5 times which further increases the ability of a polar compound to penetrate the epidermis. Any process that removes or damages the stratum corneum can enhance penetration of a xenobiotic.
1) Stratum corneum - This is the correct answer.
The epidermis (and particularly the stratum corneum) is the only layer that is important in regulating penetration of a skin contaminant.
2) Increasing hydration and disruption of the stratum corneum - This is the correct answer.
Water plays an important role in dermal absorption. Normally, the stratum corneum is partially hydrated (~7% by weight). Penetration of polar substances is about 10 times as effective as when the skin is completely dry. Additional hydration can increase penetration by 3-5 times which further increases the ability of a polar compound to penetrate the epidermis. Any process that removes or damages the stratum corneum can enhance penetration of a xenobiotic.