Knowledge Check Solutions
1) Liver - This is the correct answer.
Biotransforming enzymes are widely distributed throughout the body. However, the liver has the largest concentration of all organs and thus has a very high capacity for biotransformation.
2) An anatomical arrangement in which xenobiotics absorbed from the intestine go to the liver first rather than into the systemic circulation - This is the correct answer.
Blood leaving the gastrointestinal tract does not directly flow into the general circulatory system. Instead, it flows into the liver first via the portal vein. This is known as the "first pass" phenomena.
1) Liver - This is the correct answer.
Biotransforming enzymes are widely distributed throughout the body. However, the liver has the largest concentration of all organs and thus has a very high capacity for biotransformation.
2) An anatomical arrangement in which xenobiotics absorbed from the intestine go to the liver first rather than into the systemic circulation - This is the correct answer.
Blood leaving the gastrointestinal tract does not directly flow into the general circulatory system. Instead, it flows into the liver first via the portal vein. This is known as the "first pass" phenomena.