Knowledge Check Solutions
1) Is damaged by a toxic substance - This is the correct answer.
A target organ is an organ in which a substance exerts a toxic effect.
2) All of the above - This is the correct answer.
All of these are important factors influencing the toxicity of a substance.
3) May result in detoxification or bioactivation - This is the correct answer.
Metabolism of a xenobiotic results in either detoxification, which converts the xenobiotic to a less toxic form, or bioactivation, which converts the xenobiotic to more reactive or toxic forms. For example, a xenobiotic itself might not be carcinogenic, but a metabolite of the xenobiotic might be.
4) Selective toxicity - This is the correct answer.
Selective toxicity refers to differences in toxicity between two species simultaneously exposed, much like the antibiotic in this example.
5) Lipid solubility - This is the correct answer.
A major determinant of whether or not a toxicant will damage cells is its lipid solubility. If a toxicant is lipid-soluble, it readily penetrates cell membranes.
1) Is damaged by a toxic substance - This is the correct answer.
A target organ is an organ in which a substance exerts a toxic effect.
2) All of the above - This is the correct answer.
All of these are important factors influencing the toxicity of a substance.
3) May result in detoxification or bioactivation - This is the correct answer.
Metabolism of a xenobiotic results in either detoxification, which converts the xenobiotic to a less toxic form, or bioactivation, which converts the xenobiotic to more reactive or toxic forms. For example, a xenobiotic itself might not be carcinogenic, but a metabolite of the xenobiotic might be.
4) Selective toxicity - This is the correct answer.
Selective toxicity refers to differences in toxicity between two species simultaneously exposed, much like the antibiotic in this example.
5) Lipid solubility - This is the correct answer.
A major determinant of whether or not a toxicant will damage cells is its lipid solubility. If a toxicant is lipid-soluble, it readily penetrates cell membranes.