Knowledge Check Solutions
1) Computer models like (Q)SAR - This is the correct answer.
Part of the basis for emerging approaches to hazard identification, such as assessing for potential mutations and DNA damage, relies on (Quantitative) Structure Activity (Q)SAR methods.
2) Evaluate changes in normal cellular signaling pathways using human-relevant cells or tissues - This is the correct answer.
Adverse Outcome Pathways (AOPs) are in vitro methods that evaluate changes in normal cellular signaling pathways using human-relevant cells or tissues.
3) Yes - This is the correct answer.
Quantitative read-across can lead to a measurable value for an endpoint, such as a dose-response relationship.
1) Computer models like (Q)SAR - This is the correct answer.
Part of the basis for emerging approaches to hazard identification, such as assessing for potential mutations and DNA damage, relies on (Quantitative) Structure Activity (Q)SAR methods.
2) Evaluate changes in normal cellular signaling pathways using human-relevant cells or tissues - This is the correct answer.
Adverse Outcome Pathways (AOPs) are in vitro methods that evaluate changes in normal cellular signaling pathways using human-relevant cells or tissues.
3) Yes - This is the correct answer.
Quantitative read-across can lead to a measurable value for an endpoint, such as a dose-response relationship.